期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202000147
关键词
double-layered microneedles; interstitial skin fluid extraction; frozen spray-coating; transdermal drug delivery
资金
- Additive Manufacturing for Biological Materials program from Singapore A*STAR Science and Engineering Research Council [A18A8b0059]
- City University of Hong Kong [9610472]
- Ministry of Education -Singapore [RG49/18]
This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).
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