期刊
ADVANCED HEALTHCARE MATERIALS
卷 9, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202000527
关键词
beta-cyclodextrin; gelatin methacryloyl; microneedles; transdermal delivery; water insoluble drugs
资金
- National Institutes of Health [1R01EB024403-01, 1R01GM126831-01]
Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and beta-cyclodextrin (GelMA-beta-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-beta-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-beta-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-beta-CD MN arrays patch.
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