期刊
SCIENTIFIC REPORTS
卷 10, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-020-64841-4
关键词
-
资金
- Colleges and Universities Key Scientific Research Project of Henan Province [19zx009]
- Basic and Frontier Technology Research Program of Henan Province [132300410448]
- Science and Technology Project for Tackling Key Problems of Henan Province [182102311172]
- Science and Technology Tnnovation Talent Program of Henan Province [154100510019]
Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells derived from immature myeloid cells (IMCs). MDSCs are known to play important roles in tumor immune evasion. While we know that there are a large number of circulating and tumor-infiltrating MDSCs existing in gastric cancer (GC) patients, the phenotypic characteristics and arginase 1 (ARG1) expression levels of these MDSCs remain very unclear. In our study, flow cytometric analysis of circulating MDSCs from 20 gastric adenocarcinoma (GAC) patients found that >= 80% ARG1-expressing MDSCs were mainly early-stage MDSCs (HLA-DR(-)CD33(+)CD14(-)CD15(-)MDSCs). In addition, our investigation showed that tumor-infiltrating MDSCs from 6 GAC patients consisted of >35% ARG1-expressing naive MDSCs (HLA-DR(-)CD33(-)CD11b(-)CD14(-)CD15(-)MDSCs), >15% early-stage MDSCs and >40% monocytic MDSCs (HLA-DR(-)CD14(+)MDSCs). This preliminary study describes the phenotypic characteristics and ARG1 expression levels of MDSCs from GAC patients and shows that circulating and tumor-infiltrating ARG1-expressing cells were mainly immature and monocytic MDSCs, which provides information to better understand the mechanisms that allow gastric cancer cells to evade the immune system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据