期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 12, 期 1, 页码 27-30出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201601357
关键词
bioorganic chemistry; carbohydrates; glycosylation; peptides; peptidoglycan
资金
- Japan Society for the Promotion of Science (JSPS) [JP26102732, JP26282211, JP16H01162]
- NEXT Program [LR025]
- Council for Science and Technology Policy
- Mizutani Foundation for Glycoscience
- Grants-in-Aid for Scientific Research [26282211, 16H01885, 17K19201, 16H01162, 15H05836] Funding Source: KAKEN
Peptidoglycan (PGN) is an essential structural component of the bacterial cell wall conferring cell shape, which can be recognized by host-recognition proteins and receptors as well as bacterial surface proteins. In this work, the PGN partial structures from Enterococcus faecalis that contain a tetrasaccharide and an octasaccharide with a unique heptapeptide were synthesized via an Fmoc-strategy for elongation of the glycan chains. Namely, a 4'-O-Fmoc-protected disaccharide was utilized as the key intermediate in this efficient synthetic pathway for preparing various PGN fragments. Both the tetrasaccharide and octasaccharide with the unique heptapeptide were successfully synthesized for the first time.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据