相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Protein Misfolding and ER Stress in Huntington's Disease
Talya Shacham et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2019)
PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjogren syndrome
Valentina Grande et al.
HUMAN MOLECULAR GENETICS (2018)
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease
Gabriela Mercado et al.
NEUROBIOLOGY OF DISEASE (2018)
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B
Agnieszka Krzyzosiak et al.
CELL (2018)
Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress
Shauna H. Yuan et al.
HUMAN MOLECULAR GENETICS (2018)
Therapeutic approaches to Huntington disease: from the bench to the clinic
Nicholas S. Caron et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Huntington's Disease and Diabetes: Chronological Sequence of its Association
Maria Teresa Montojo et al.
JOURNAL OF HUNTINGTONS DISEASE (2017)
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice
Mark Halliday et al.
BRAIN (2017)
PERK activation mitigates tau pathology in vitro and in vivo
Julius Bruch et al.
EMBO MOLECULAR MEDICINE (2017)
Endoplasmic reticulum stress: The cause and solution to Huntington's disease?
Yuwei Jiang et al.
BRAIN RESEARCH (2016)
Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease
Wenzhong Yang et al.
NEUROBIOLOGY OF AGING (2016)
Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation
Ryuta Ishimura et al.
ELIFE (2016)
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
Helois Radford et al.
ACTA NEUROPATHOLOGICA (2015)
Early Neurodegeneration in the Brain of a Child Without Functional PKR-like Endoplasmic Reticulum Kinase
Julius Bruch et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)
Proteostasis control by the unfolded protein response
Claudio Hetz et al.
NATURE CELL BIOLOGY (2015)
Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS
Fernando G. Vieira et al.
PLOS ONE (2015)
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
Indrajit Das et al.
SCIENCE (2015)
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
M. Halliday et al.
CELL DEATH & DISEASE (2015)
Impaired motor speech performance in Huntington's disease
Sabine Skodda et al.
JOURNAL OF NEURAL TRANSMISSION (2014)
Huntington disease: natural history, biomarkers and prospects for therapeutics
Christopher A. Ross et al.
NATURE REVIEWS NEUROLOGY (2014)
ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin
Julia Leitman et al.
PLOS ONE (2014)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
Julie A. Moreno et al.
SCIENCE TRANSLATIONAL MEDICINE (2013)
Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress
Julia Leitman et al.
NATURE COMMUNICATIONS (2013)
Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
Jeffrey M. Axten et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntington's Disease
R. Vidal et al.
CURRENT MOLECULAR MEDICINE (2011)
Sex-Dependent Changes in Social Behaviors in Motor Pre-Symptomatic R6/1 Mice
Susanna Pietropaolo et al.
PLOS ONE (2011)
Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
Pavel Tsaytler et al.
SCIENCE (2011)
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Peter Walter et al.
SCIENCE (2011)
Structural Determinants of PERK Inhibitor Potency and Selectivity
Hong Wang et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2010)
Diabetes mellitus in Huntington disease
Lindsay A. Farrer
CLINICAL GENETICS (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
Stephan J. Guyenet et al.
Jove-Journal of Visualized Experiments (2010)
Mouse models of Huntington's disease and methodological considerations for therapeutic trials
Robert J. Ferrante
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
Rrs1 Is Involved in Endoplasmic Reticulum Stress Response in Huntington Disease
Alisia Carnemolla et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins
Sami Reijonen et al.
EXPERIMENTAL CELL RESEARCH (2008)
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
Martin L. Duennwald et al.
GENES & DEVELOPMENT (2008)
Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice
EC Stack et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents
MJ Hunt et al.
EXPERIMENTAL BRAIN RESEARCH (2005)
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient β-cell mass and exocytosis
M Björkqvist et al.
HUMAN MOLECULAR GENETICS (2005)
A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
M Boyce et al.
SCIENCE (2005)
ER stress and the unfolded protein response
M Schröder et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Phosphorylation of the a subunit of eukaryotic initiation factor 2 is required for activation of NF-κB in response to diverse cellular stresses
HY Jiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene
A Biason-Lauber et al.
DIABETES (2002)
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
I Novoa et al.
JOURNAL OF CELL BIOLOGY (2001)
Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells
F Trettel et al.
HUMAN MOLECULAR GENETICS (2000)
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
CY Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)