期刊
SCIENTIFIC REPORTS
卷 10, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-63331-x
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资金
- Science and Technology Agency of Sichuan Province [20ZDYF2976, 20ZDYF3190]
To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China's healthy population by using the laboratory information system database. A total of 86957 periodic health examination individuals of the medical examination center in West China Hospital from 2016 to 2018 were included in the study. We used the Box-Cox conversion combined with the Tukey method to normalize the data and eliminate the outliers, and the normal distribution method and the nonparametric method to estimate the 95% distribution RI. The NSE 95% distribution RI we established in healthy populations in southwest China through normal distribution and nonparametric method were 0-19.64ng/ml and 0-20.46ng/ml, respectively. The obtained RIs verification conformed to the standard and was significantly different from the reagent instruction(P<0.05). The RI established by the nonparametric method was superior to the RI of the normal distribution method and reagent instruction(P<0.05). We initially established an NSE RI that was suitable for the healthy southwest China population. The Box-Cox conversion combined with the Tukey method and nonparametric method is a reliable and straightforward indirect method for reference interval acquisition, which is suitable for the promotion and application of clinical laboratory.
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