期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 17, 页码 5894-5898出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600234
关键词
amides; amines; boronic acid; synthetic methods; transamidation
资金
- ANR NeoACAT [ANR-JC-12]
- Labex SynOrg [ANR-11-LABX-0029]
- region Normandie
A highly efficient and mild transamidation of amides with amines co-catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral alpha-amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron-derived Lewis acidity rather than an improved Bronsted acidity of acetic acid.
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