期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 50, 页码 17958-17961出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604621
关键词
amino acid; C-H activation; cyanation; heterocycle; manganese
资金
- European Research Council under the European Community/ERC [307535]
- Chinese Scholarship Program
The manganese-catalyzed cyanation of inert C-H bonds was achieved within a heterobimetallic catalysis regime. The manganese(I) catalysis proved widely applicable and enabled C-H cyanations on indoles, pyrroles and thiophenes by facile C-H manganesation. The robustness of the manganese catalyst set the stage for the race-mization-free C-H cyanation of amino acids with excellent levels of positional and chemo selectivity by the new cyanating agent NCFS. Experimental and computational mechanistic studies provided strong support for a synergistic heterobimetallic activation mode, facilitating the key C-C formation.
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