期刊
NUTRIENTS
卷 12, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/nu12051328
关键词
mumefural; single oral dose toxicity; repeated oral dose toxicity; ICR mice
资金
- The R&D Convergence Program of the Republic of Korea National Research Council of Science and Technology (NST) [CRC-15-04-KIST, KSN 1621850, NSN1522380]
- NST-Korea Institute of Science and Technology (KIST) Postdoctoral Research Fellowship for Young Scientists at the Korea Institute of Oriental Medicine in South Korea
Mumefural is a bioactive compound derived from the processed fruit ofPrunus mumeSieb. et Zucc., a traditional health food; however, its safety has not been evaluated. We investigated the toxicity of mumefural through single and repeated oral administration at doses of 1250, 2500, and 5000 mg/kg in Institute of Cancer Research (ICR) mice. The acute toxicity assessment was not associated with adverse effects or death. Similarly, the subacute (four weeks) toxicity assessment did not reveal any mumefural-associated mortality, abnormal organ damage, or altered clinical signs, body weight, food consumption, or hematological parameters. However, albumin/globulin ratio and chloride ion levels were significantly increased in male mice treated with mumefural at >= 2500 mg/kg. Female mice exhibited significantly higher levels of chloride, sodium, and potassium ions, at a dose of 5000 mg/kg. Furthermore, the administration of 2500 and 5000 mg/kg mumefural decreased the absolute weight of spleen in male mice. These findings indicated that the approximate lethal dose of mumefural in ICR mice was >5000 mg/kg. No significant mumefural toxicity was observed at <= 5000 mg/kg. Our findings provide a basis for conducting future detailed studies to evaluate reproductive, neurological, genetic, and chronic toxicity of mumefural.
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