期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 47, 页码 16782-16785出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604105
关键词
copper catalysts; molecular imaging; radiochemistry; radioiodination; radiopharmaceuticals
资金
- National Key Basic Research Program of China [2014CB744503]
- National Natural Science Foundation of China [21271030, 81471707]
- Fundamental Research Funds for the Central Universities [20720150063, 2013SH009]
A convenient and quantitative radioiodination method by copper-mediated cross-coupling of aryl boronic acids was developed. The mild labeling conditions, ready availability of the boronic acid substrate, simple operation, broad functional group tolerance and excellent radiochemical yield (RCY) make this a practical strategy for radioiodine labeling without further purification.
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