期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 48, 页码 17112-17129出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201602298
关键词
bioactive hybrids; disulfide rebridging; drug delivery; multimodal proteins; site-selective protein modifications
资金
- Innovative Training Network (ITN) under the Horizon2020 program
- ERC Synergy Grant [319130-BioQ]
- EU Project Hyperdiamond supported under Horizon program
- German Ministry of Research and Education (BMBF)
- project Selekomm within the Biotechnologie2020+ initiative
The synthetic transformation of polypeptides with molecular accuracy holds great promise for providing functional and structural diversity beyond the proteome. Consequently, the last decade has seen an exponential growth of site-directed chemistry to install additional features into peptides and proteins even inside living cells. The disulfide rebridging strategy has emerged as a powerful tool for site-selective modifications since most proteins contain disulfide bonds. In this Review, we present the chemical design, advantages and limitations of the disulfide rebridging reagents, while summarizing their relevance for synthetic customization of functional protein bioconjugates, as well as the resultant impact and advancement for biomedical applications.
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