期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 42, 页码 14806-14811出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201601714
关键词
biodegradable; bridged silsesquioxanes; drug delivery; enzymes; nanoparticles
资金
- King Abdullah University of Science and Technology
- University of California, Los Angeles
We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
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