期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 4, 页码 970-975出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604855
关键词
asymmetric catalysis; chiral alcohols; ferrocenyl; ketones; ligands
资金
- Wuhan University [203410100064]
- Important Sci-Tech Innovative Project of Hubei Province [2015ACA058]
- 111 Project of the Ministry of the Education of China
- National Natural Science Foundation of China [21372179, 21432007, 21502145, 21372266, 51302327]
We have successfully developed a series of novel and modular ferrorence-based amino-phosphine-alcohol (f-Amphol) ligands, and applied them to iridium-catalyzed asymmetric hydrogenation of various simple ketones to afford the corresponding chiral alcohols with excellent enantioselectivities and conversions (98-99.9% ee, >99% conversion, turnover number up to 200 000). Control experiments and density functional theory (DFT) calculations have shown that the hydroxyl group of our f-Amphol ligands played a key role in this asymmetric hydrogenation.
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