期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 21, 页码 7084-7089出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201601245
关键词
13-methylprotoberberine; aporhoeadane; protoberberine; redox-A(3) reaction; total synthesis
资金
- HKUST
- Research Grant Council of Hong Kong [ECS 605912, GRF 605113, GRF 16305314]
A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A(3) reaction, Pd-catalyzed reductive carbocyclization, and PtO2-catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据