期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 4, 页码 946-952出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604709
关键词
glycopeptides; native chemical ligation; oxidative deselenization; peptides; synthesis
资金
- ARC Future Fellowship [FT130100150]
- Discovery Project [DP160101324]
The use of native chemical ligation at selenocysteine (Sec) residues with peptide thioesters and additive-free selenocystine ligation with peptides bearing phenyl selenoesters, in concert with one-pot oxidative deselenization chemistry, is described. These approaches provide a simple and rapid method for accessing native peptides with serine in place of Sec at the ligation junction. The efficiency of both variants of the one-pot ligation-oxidative deselenization chemistry is probed through the synthesis of a MUC5AC-derived glycopeptide.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据