期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 52, 页码 18756-18759出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201605265
关键词
1,3-bisfunctionalization; cyclopropane; enantioselectivity; organocatalysis; sulfur
资金
- European Research Council (ERC Consolidator Grant GAINBYSTRAIN)
- Studienstiftung des deutschen Volkes
meso-Cyclopropyl carbaldehydes are treated in the presence of an organocatalyst with sulfenyl and selenyl chlorides to afford 1,3chlorochal cogenated products. The transformation is achieved by a merged iminium-enamine activation. The enantioselective desymmetrization reaction, leading to three adjacent stereocenters, furnished the target products in complete regioselectivity and moderate to high diastereo- and enantioselectivities (d.r. up to 15:1 and e.r. up to 93:7).
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