期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 10, 页码 3513-3518出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201504534
关键词
alkyne; amination; chalcogen; copper; selectivity
资金
- National Natural Science Foundation of China [21372041, 21402025]
- Fundamental Research Funds for the Central Universities [2412015KJ014]
By using N-fluorobenzenesulfonimide as both the oxidant and the amination reagent, we have realized the first example of the intermolecular chalcogenative amination of alkynes, which grants facile, highly regio- and stereoselective access to chalcogenated enamides. The reaction features mild conditions, high yields and selectivities, remarkably broad substrate scope, and excellent functional group tolerance. Mechanistic studies indicate the in situ generated chalcogen imidates to be the actual reactive species, which in turn, has clarified the mechanism of related transformations. These reactions represent significant additions to the development of the highly selective amino bisfunctionalization of alkynes.
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