期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 13, 页码 4521-4527出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201504731
关键词
dyes; pigments; lanthanides; luminescence; magnetic properties; nanoparticles
资金
- Fund for scientific research Flanders (FWO-V) [G.0618.11N]
- Agency for Innovation by Science and Technology in Flanders (IWT)
- IWT
- French Community of Belgium for support through ARC Programs [AUWB-2010-10/15-UMONS-5]
- Fonds National de la Recherche Scientifique (FNRS)
- Belgian Science Policy (UIAP VII program)
- COST Actions [D38, TD1004]
- European Network of Excellence EMIL (European Molecular Imaging Laboratories) program [LSCH-2004-503569]
- Center for Microscopy and Molecular Imaging (CMMI)
- European Regional Development Fund
- Walloon Region
A new prototype consisting of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles decorated with europium(III) ions encapsulated in a DO3A organic scaffold was designed as a platform for further development of bimodal contrast agents for MRI and optical imaging. The USPIO nanoparticles act as negative MRI contrast agents, whereas the europium(III) ion is a luminophore that is suitable for use in optical imaging detection. The functionalized USPIO nanoparticles were characterized by TEM, DLS, XRD, FTIR, and TXRF analysis, and a full investigation of the relaxometric and optical properties was conducted. The typical luminescence emission of europium(III) was observed and the main red emission wavelength was found at 614nm. The relaxometric study of these ultrasmall nanoparticles showed r(2) values of 114.8mm(Fe)(-1)s(-1) at 60MHz, which is nearly double the r(2) relaxivity of Sinerem((R)).
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