4.8 Article

Site-Selective and Product Chemoselective Aliphatic C-H Bond Hydroxylation of Polyhydroxylated Substrates

期刊

ACS CATALYSIS
卷 10, 期 8, 页码 4702-4709

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b05423

关键词

Aliphatic hydroxylation; polarity reversal; fluorinated alcohol solvents; hydrogen atom transfer; polyols; manganese; hydrogen peroxide

资金

  1. Spanish Ministry of Science [PGC2018-101737-B-I00, BES-2016-076349]
  2. Generalitat de Catalunya (ICREA Academia Award) [2017 SGR 00264]

向作者/读者索取更多资源

Site-selective and product chemoselective aliphatic C-H bond oxidation of 1,2-diols and of polyhydroxylated substrates using iron and manganese catalysts and hydrogen peroxide as terminal oxidant is described. The reaction capitalizes on the use of fluorinated alcohol solvents such as 2,2,2-trifluoroethanol (TFE) and 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP), which exert a strong polarity reversal in the hydroxyl moieties of 1,2-diols via hydrogen bonding, in turn translating into a strong deactivation of proximal C-H bonds against a HAT initiated oxidation by the putative high-valent and electrophilic metal-oxo species. As a result, site-selective and product chemoselective oxidation of complex polyfunctional molecules such as steroids, sugars, and pharmaceuticals is described, where exclusive or predominant C-H bond hydroxylation at a remote and nonactivated site takes place. The current report discloses HAT initiated hydroxylations in fluorinated alcohol solvents as methods displaying orthogonal chemoselectivity to contemporary alcohol oxidations providing a useful tool for synthetic planning in densely functionalized molecules.

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