4.8 Article

HIV-associated gut dysbiosis is independent of sexual practice and correlates with noncommunicable diseases

期刊

NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -

出版社

NATURE PORTFOLIO
DOI: 10.1038/s41467-020-16222-8

关键词

-

资金

  1. Cancer Research Institute Irvington Postdoctoral Fellowship Award
  2. National Institutes of Health Intramural AIDS Research Fellowship
  3. intramural research program of NIAID/NIH
  4. Netherlands Organization for Health Research and Development (ZonMW) [300020007]
  5. AIDS Fonds [2009063]
  6. NIH intramural funding [AI001226-01]
  7. Gilead Sciences
  8. ViiV Healthcare
  9. Janssen Pharmaceuticals N.V.
  10. Merck Co.
  11. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI001121, ZIAAI001029, ZICAI001233, ZICAI001226, ZIAAI001115] Funding Source: NIH RePORTER

向作者/读者索取更多资源

Loss of gut mucosal integrity and an aberrant gut microbiota are proposed mechanisms contributing to chronic inflammation and increased morbidity and mortality during antiretroviral-treated HIV disease. Sexual practice has recently been uncovered as a major source of microbiota variation, potentially confounding prior observations of gut microbiota alterations among persons with HIV (PWH). To overcome this and other confounding factors, we examine a well-powered subset of AGEhIV Cohort participants comprising antiretroviral-treated PWH and seronegative controls matched for age, body-mass index, sex, and sexual practice. We report significant gut microbiota differences in PWH regardless of sex and sexual practice including Gammaproteobacteria enrichment, Lachnospiraceae and Ruminococcaceae depletion, and decreased alpha diversity. Men who have sex with men (MSM) exhibit a distinct microbiota signature characterized by Prevotella enrichment and increased alpha diversity, which is linked with receptive anal intercourse in both males and females. Finally, the HIV-associated microbiota signature correlates with inflammatory markers including suPAR, nadir CD4 count, and prevalence of age-associated noncommunicable comorbidities. The role of sexual practice in HIV-associated gut microbiota remains poorly understood. Here, in a cohort of chronically treated HIV-infected people, the authors show microbiome signatures to be independent of sex and sexual practice and that the extent of dysbiosis correlates with nadir CD4, inflammatory markers, and comorbidities.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据