期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 11, 页码 3671-3675出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503944
关键词
bioluminescence imaging; C-H activation; luciferase; luciferin; Sonogashira coupling
资金
- National Institutes of Health (NIH) [R01M107630]
- National Institute of General Medical Sciences of the NIH [8P41M103540]
- UC Irvine
Herein, the synthesis and characterization of an alkyne-modified luciferin is reported. This bioluminescent probe was accessed using C-H activation methodology and was found to be stable in solution and capable of light production with firefly luciferase. The luciferin analogue was also cell permeant and emitted more redshifted light than d-luciferin, the native luciferase substrate. Based on these features, the alkynyl luciferin will be useful for a variety of imaging applications.
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