期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-020-16022-0
关键词
-
资金
- Wellcome Trust Strategic Award Stratifying Resilience and Depression Longitudinally (STRADL) [104036/Z/14/Z]
- MRC Mental Health Data Pathfinder Award [MC_PC_17209]
- UK Biobank [4844]
- Biotechnology and Biological Sciences Research Council (BBSRC)
- Medical Research Council (MRC)
- US National Institute of Mental Health [5 U01MH109528-03]
- China Scholarship Council [201506040037]
- JMAS SIM fellowship from the Royal College of Physicians of Edinburgh
- ESAT College Fellowship from the University of Edinburgh
- Sir Henry Wellcome Postdoctoral Fellowship [213674/Z/18/Z]
- 2018 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation [27404]
- Age UK (Disconnected Mind Project)
- Sackler Trust
- Wellcome Trust [213674/Z/18/Z] Funding Source: Wellcome Trust
- MRC [MC_PC_17209, MR/T04604X/1, MR/L023784/2, G0200243, UKDRI-3003] Funding Source: UKRI
Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N=10,674) and replication (N=11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (beta: 0.125 to 0.868, p(FDR)<0.043). Several behavioural traits are also associated with depression-PRS (beta: 0.014 to 0.180, p(FDR): 0.049 to 1.28x10(-14)) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据