期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 9, 页码 2920-2924出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201504880
关键词
amides; azides; C-H activation; homogeneous catalysis; iridium
资金
- National Natural Science Foundation of China [21332005, 21472085]
An iridium-catalyzed C-H amination of arenes with a wide substrate scope is reported. Benzamides with electron-donating and -withdrawing groups and linear, branched, and cyclic alkyl azides are all applicable. Cesium carboxylate is crucial for both reactivity and regioselectivity of the reactions. Many biologically relevant molecules, such as amino acid, peptide, steroid, sugar, and thymidine derivatives can be introduced to arenes with high yields and 100% chiral retention.
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