期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 30, 页码 10355-10359出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201602338
关键词
2-oxazolidinones; antibiotics; carbon dioxide; density functional calculations; guanidine superbases
资金
- Magnus Ehrnrooth foundation
- Spanish MINECO-FEDER [CTQ2013-44303-P]
The multicomponent assembly of pharmaceutically relevant N-aryl-oxazolidinones through the direct insertion of carbon dioxide into readily available anilines and dibromoalkanes is described. The addition of catalytic amounts of an organosuperbase such as Barton's base enables this transformation to proceed with high yields and exquisite substrate functional-group tolerance under ambient CO2 pressure and mild temperature. This report also provides the first proof-of-principle for the single-operation synthesis of elusive seven-membered ring cyclic urethanes.
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