期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 20, 期 2, 页码 854-859出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2020.8742
关键词
quercetin; inflammation; epilepsy
资金
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 'Qinglan Project' of the Young and Middle-aged Academic Leader of Jiangsu College and University
- '333 Project' Award of Jiangsu Province
- Cultivate National Science Fund for Distinguished Young Scholars of Jiangsu Normal University
- Major Fundamental Research Program of the Natural Science Foundation of the Jiangsu Higher Education Institutions of China [13KJA180001]
- National Natural Science Foundation of China [81571055, 81400902, 81271225, 81171012, 30950031]
Epilepsy is a prevalent neurological disorder and it is a significant health risk, affecting >50 million people worldwide. The development of novel and appropriate strategies is required for ameliorating the progression and/or limiting the detrimental consequences of epilepsy. In the current study, kainic acid (KA), a neurotoxin, was used to induce seizures in mice. The flavonoid quercetin has recently been reported to have neuroprotective effects. Therefore, the effects of quercetin on KA-induced epilepsy and the potential underlying molecular mechanisms were examined. It was noted that quercetin attenuated the KA-induced seizure score and proinflammatory cytokine production, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta), and activation of nuclear factor kappa B (NF-kappa B) in mice. Quercetin attenuated KA-induced proinflammatory cytokine (TNF-alpha and IL-1 beta) release from microglia cells, as well as activation of NF-kappa B and ionized calcium binding adapter molecule 1 in microglia cells. Therefore, quercetin inhibited KA-induced epilepsy by microglia cell inactivation and the production of NF-kappa B, TNF-alpha and IL-1 beta.
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