期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 19, 期 6, 页码 3604-3610出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2020.8655
关键词
miR-454; cylindromatosis; SGC-7901 cells; oxaliplatin
资金
- Science Fund of the National Natural Science Foundation of China [81502113]
- Wuhan Clinical Research Center for Peritoneal Carcinomatosis [2015060911020462]
MicroRNA-454 (miR-454), is involved in the progression of various types of cancers. The present study aimed to evaluate the effect of miR-454 on the progression of gastric cancer. SGC-7901 cells overexpressing or silencing miR454 were constructed via transfection and the survival rate of the cells was determined. The relationship between miR-454 and cylindromatosis (CYLD) was explored and the influence of miR-454 on oxaliplatin resistance was investigated in SGC-7901 cells. It was determined that overexpression of miR-454 increased the number of colonies and reduced apoptosis rate of SGC-7901 cells. The CYLD gene was identified as a direct target of miR-454. miR-454 overexpression downregulated the expression of CYLD, leading to an increase in SGC-7901 cell proliferation. Finally, miR-454 was also demonstrated to induce resistance to oxaliplatin in gastric cancer cells. In conclusion, the present in vitro findings suggested that miR-454 might be a novel therapeutic target for gastric cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据