期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 35, 页码 12270-12273出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201602730
关键词
copper; diazo compounds; fluorine; fluoroalkylthiolation; synthetic methods
alpha-Diazo esters are smoothly converted into the corresponding trifluoromethyl thio- or selenoethers by reaction with Me4NSCF3 or Me4NSeCF3, respectively, in the presence of catalytic amounts of copper thiocyanate. This straightforward method gives high yields under neutral conditions at room temperature and is applicable to a wide range of functionalized molecules, including diverse -amino acid derivatives. It is well-suited for the late-stage introduction of trifluoromethylthio or -seleno groups into drug-like molecules.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据