期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 46, 页码 16446-16449出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603974
关键词
C-13 NMR; hyperpolarization; parahydrogen; PHIP; polarization transfer
资金
- Russian Science Foundation [14-13-00445]
- RFBR [14-03-93183]
- FASO Russia [0333-2014-0001]
- RSF grant [14-23-00146]
- FASO [0303-2015-0010]
- [MK-4498.2016.3]
- Russian Science Foundation [14-13-00445, 14-23-00146] Funding Source: Russian Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1416268] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1416432] Funding Source: National Science Foundation
A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce C-13-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO2 catalyst with a metal loading of 23.2wt% produced strongly hyperpolarized C-13-enriched ethyl acetate-1-C-13 detected at 9.4 T. An approximately 14-fold C-13 signal enhancement was detected using circa 50% parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to C-13 nuclei. This first observation of C-13 PHIP-hyperpolarized products over a supported metal catalyst in an aqueous medium opens up new possibilities for production of catalyst-free aqueous solutions of nontoxic hyperpolarized contrast agents for a wide range of biomolecules amenable to the parahydrogen induced polarization by side arm hydrogenation (PHIP-SAH) approach.
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