期刊
CELL DEATH & DISEASE
卷 11, 期 3, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41419-020-2399-y
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资金
- MIUR PRIN grant [2017WLKYAM_1, 2017WLKYAM_3]
- Medical Research Council (MRC) Biomedical Catalyst grant [MR/L005069/1]
- Bloodwise project [15003]
- NIHR Imperial (BRC) Push for Impact Award [WIIS_P81135]
- MRC [MR/L005069/1] Funding Source: UKRI
Escaping programmed cell death is a hallmark of cancer. NF-kappa B transcription factors are key regulator of cell survival and aberrant NF-kappa B signaling has been involved in the pathogenesis of most human malignancies. Although NF-kappa B is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-kappa B. This review discusses how the reciprocal regulation of NF-kappa B, autophagy and programmed cell death affect cancer development and progression.
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