期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 3, 页码 533-536出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201604376
关键词
anticancer agents; aza-Cope-Mannich cyclization; oxazolidine; rearrangement; synthesis design
资金
- DST, New Delhi
- UGC-New Delhi
- IIT-Hyderabad
A facile and convergent approach has been developed for the stereoselective construction of biologically important polyhydroxylated 2-acyl indolizidine framework using aza-Cope rearrangement-Mannich cyclization as a key step. The generality of this methodology is demonstrated with various lactol-tosylates derived from carbohydrates. The presented method provides an easy access to indolizidine-and tetrahydroindolizine-based iminosugar derivatives in good yields.
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