21st Century Advances in Multimodality Imaging of Obesity for Care of the Cardiovascular Patient

Although obesity is typically defined by body mass index criteria, this does not differentiate true body fatness, as this includes both body fat and muscle. Therefore, other fat depots may better define cardiometabolic and cardiovascular disease (CVD) risk imposed by obesity. Data from translational, epidemiological, and clinical studies over the past 3 decades have clearly demonstrated that accumulation of adiposity in the abdominal viscera and within tissue depots lacking physiological adipose tissue storage capacity (termed ectopic fat) is strongly associated with the development of a clinical syndrome characterized by atherogenic dyslipidemia, hyperinsulinemia/glucose intolerance/type 2 diabetes mellitus, hypertension, atherosclerosis, and abnormal cardiac remodeling and heart failure. This state-of-the-art paper discusses the impact of various body fat depots on cardiometabolic parameters and CVD risk. Specifically, it reviews novel and emerging imaging techniques to evaluate adiposity and the risk of cardiometabolic diseases and CVD. (C) 2021 by the American College of Cardiology Foundation.

Automated summary

The accumulation of adiposity in the abdominal viscera and ectopic fat is strongly associated with the development of cardiometabolic diseases and cardiovascular risks, as demonstrated by research over the past three decades. Novel imaging techniques are being reviewed to evaluate the impact of various body fat depots on these health parameters.