期刊
JOURNAL OF OPTICS
卷 22, 期 5, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/2040-8986/ab8285
关键词
optical coherence tomography; speckle reduction; angular compounding imaging; Master-Slave OCT; biological imaging
类别
资金
- Erasmus+ programme
- Engineering and Physical Sciences Research Council (EPSRC), 'REBOT' project [EP/N019318/1]
- Biotechnology and Biological Sciences Research Council (BBSRC), '5DHiResE' project [BB/S016643/1]
- National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust (NIHR)
- UCL Institute of Ophthalmology, University College London
- Royal Society Wolfson research merit award
- BBSRC [BB/S016643/1] Funding Source: UKRI
- EPSRC [EP/N019318/1] Funding Source: UKRI
In this paper, an angular compounding method to achieve speckle contrast reduction in optical coherence tomography (OCT) imaging is explored in detail. The angular compounding approach involves collecting multiple images at different angles of incidence, registering the images to correct for induced distortions, and then incoherently summing the images to reduce speckle. The method was experimentally demonstrated with a spectrometer-based Master-Slave enhanced OCT instrument capable of directly generating en-face images. We have investigated the impact of the angular range and number of averaged frames on the degree of speckle artefact reduction, as well as the effect on image resolution and sharpness. The minimum angular step necessary to secure a sufficiently small speckle pattern correlation between the images has also been determined, and the method has subsequently been validated on a biological sample (potato cells).
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