期刊
出版社
WILEY
DOI: 10.1002/wnan.1643
关键词
cancer therapy; nanomaterial; near-infrared light; prodrug activation
资金
- Beijing University of Chemical Technology [PYBZ1825, XK1802-8, buctrc201915]
- Ministry of Science and Technology of the People's Republic of China [2016YFA0201500]
- National Natural Science Foundation of China [21822802, 51572271, 51772018]
Nanomaterials-based prodrug activation systems have been widely explored in cancer therapy, aiming at overcoming limited dosage formulation, systemic toxicity, and insufficient pharmacokinetic performance of parent drugs. For better delivery control, various stimuli systems, especially nanomaterials-based ones, have come to the forefront. Among them, near-infrared (NIR) light takes advantage of on-demand/site-specific regulation and non-invasiveness. In this review, we will address the developments of nanomaterials-based prodrug over the last decade, the activation mechanisms, and bioapplications under NIR light triggering. The advantages and limitations of NIR-triggered prodrug activation strategies and the perspectives of the next-generation prodrug nanomedicine will also be summarized. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies
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