期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 28, 页码 9784-9791出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600125
关键词
aggregation-induced emission; cell-imaging; red-NIR fluorescence; solvatochromism; Stokes shift
资金
- Ministry of Science and Technology of China [2013CB834704]
- National Science Foundation of China [51573158, 51273175]
- Research Grants Council of Hong Kong [16301614, N_HKUST604/14, N_HKUST620/11]
- Zhejiang Innovative Research Team Program [2013TD02]
- Guangdong Innovative Research Team Program [201101C0105067115]
A tetraphenylethene (TPE) derivative modified with the strong electron acceptor 2-dicyano-methylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) was obtained in high yield by a simple two-step reaction. The resultant TPE-TCF showed evident aggregation-induced emission (AIE) features and pronounced solvatochromic behavior. Changing the solvent from apolar cyclohexane to highly polar acetonitrile, the emission peak shifted from 560 to 680 nm (120 nm redshift). In an acetonitrile solution and in the solid powder, the Stokes shifts are as large as 230 and 190 nm, respectively. The solid film emits red to near-IR (red-NIR) fluorescence with an emission peak at 670 nm and a quantum efficiency of 24.8 %. Taking the advantages of red-NIR emission and high efficiency, nanoparticles (NPs) of TPE-TCF were fabricated by using tat-modified 1,2-distearoylsn-glycero-3-phosphor- ethanol-amine-N-[methoxy-(polyethyl-eneglycol)-2000] as the encapsulation matrix. The obtained NPs showed perfect membrane penetrability and high fluorescent imaging quality of cell cytoplasm. Upon co-incubation with 4,6-diamidino-2-phenylindole (DAPI) in the presence of tritons, the capsulated TPE-TCF nanoparticles could enter into the nucleus and displayed similar staining properties to those of DAPI.
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