期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 34, 页码 12189-12198出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201601918
关键词
antioxidants; pulse radiolysis; radical reactions; selenides; selenoxides
资金
- CSIR
Understanding electron-transfer processes is crucial for developing organoselenium compounds as antioxidants and anti-inflammatory agents. To find new redoxactive selenium antioxidants, we have investigated one-electron-transfer reactions between hydroxyl ((OH)-O-center dot) radical and three bis(alkanol)selenides (SeROH) of varying alkyl chain length, using nanosecond pulse radiolysis. (OH)-O-center dot radical reacts with SeROH to form radical adduct, which is converted primarily into a dimer radical cation (>Se therefore Se)(+) and alpha-{bis-(hydroxyl alkyl)}-selenomethine radical along with a minor quantity of an intramolecularly stabilized radical cation. Some of these radicals have been subsequently converted to their corresponding selenoxide, and formaldehyde. Estimated yield of these products showed alkyl chain length dependency and correlated well with their antioxidant ability. Quantum chemical calculations suggested that compounds that formed more stable (> Se therefore Se<)(+), produced higher selenoxide and lower formaldehyde. Comparing these results with those for sulfur analogues confirmed for the first time the distinctive role of selenium in making such compounds better antioxidants.
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