期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 46, 期 7, 页码 1565-1583出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2020.03.013
关键词
Drug delivery; Endothelial cells; Endothelial barrier; Endothelial membrane; Microbubble; Ultrasound; Permeability; Vascular effects
资金
- Inserm Collaboration Agreement - Therasound
Microbubble-assisted ultrasound has emerged as a promising method for local drug delivery. Microbubbles are intravenously injected and locally activated by ultrasound, thus increasing the permeability of vascular endothelium for facilitating extravasation and drug uptake into the treated tissue. Thereby, endothelial cells are the first target of the effects of ultrasound-driven microbubbles. In this review, the in vitro and in vivo bioeffects of this method on endothelial cells are described and discussed, including aspects on the permeabilization of biologic barriers (endothelial cell plasma membranes and endothelial barriers), the restoration of their integrity, the molecular and cellular mechanisms involved in both these processes, and the resulting intracellular and intercellular consequences. Finally, the influence of the acoustic settings, microbubble parameters, treatment schedules and flow parameters on these bioeffects are also reviewed. (E-mail: Jean-michel.escoffre@univ-tours.fr) (c) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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