期刊
TRENDS IN NEUROSCIENCES
卷 43, 期 7, 页码 458-466出版社
CELL PRESS
DOI: 10.1016/j.tins.2020.04.003
关键词
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资金
- National Institute of Neurological Disorders and Stroke (US National Institutes of Health) [R01NS100366, RF1AG057575]
- National Institute on Aging (US National Institutes of Health) [R01NS100366, RF1AG057575]
- US Army Research Office [MURI W911NF1910280]
- Fondation Leducq Transatlantic Networks of Excellence Program
- Novo Nordisk Foundation
- Lundbeck Foundation
- EU Horizon 2020 research and innovation programme [666881]
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-beta and other proteins. As such, the glymphatic-lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.
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