期刊
TRENDS IN MOLECULAR MEDICINE
卷 26, 期 10, 页码 936-952出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.molmed.2020.03.012
关键词
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资金
- JSPS Overseas Research Fellowships [201860169, 201870008, 1U19 AG062418-01A1, AG10124]
The stereotypical spread of pathological protein inclusions and clinicopathological heterogeneity are well described in neurodegenerative diseases. Accumulating evidence suggests that the former can be attributed to consecutive cell-to-cell transmission of pathological proteins between anatomically connected brain regions, while the latter has been hypothesized to result from the spread of conformationally distinct pathological protein aggregates, or strains. These emerging concepts have dramatically changed our understanding of neurodegenerative diseases. In this review, we first summarize the background and recent findings underpinning these concepts with a focus on two major pathological proteins: tau and alpha-synuclein. We then discuss their clinical implications for tauopathies and synucleinopathies and propose a working hypothesis for future research.
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