期刊
TRENDS IN IMMUNOLOGY
卷 41, 期 4, 页码 341-354出版社
CELL PRESS
DOI: 10.1016/j.it.2020.02.005
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资金
- Deutsche Forschungsgemeinschaft (DFG) [GR3946/3-1, CRCTR128 A09, ME4050/4-1, ME4050/8-1]
- ERA-Net for Research on Rare Diseases
- Innovative Medical Research (IMF) program of the University Munster
- Ministerium fur Innovation, Wissenschaft und Forschung (MIWF) des Landes Nordrhein-Westfalen
- German Ministry for Education and Research (BMBF) [01GI1603A]
- European Union
- Interdisciplinary Center for Clinical Studies Munster [Kl3/010/19]
- Deutsche Forschungsgemeinschaft [CRCTR128 A08, CRC1009 A03, CRCTR128 B01, CRCTR128]
- German Ministry for Education and Research
- Interdisciplinary Center for Clinical Studies (IZKF) Munster
- Innovative Medical Research Munster
- Else Kroner Fresenius Foundation
- Fresenius Foundation
- Hertie Foundation
- NRW Ministry of Education and Research
- RE Children's Foundation
Understanding neuroimmunological disorders is essential for developing new diagnostic and therapeutic strategies. Rodent models have provided valuable insights, but are sometimes equated with their human counterparts. Here, we summarize how novel technologies may enable an improved human-focused view of immune mechanisms. Recent studies have applied these new technologies to the brain parenchyma, its surrounding cerebrospinal fluid, and peripheral immune compartments. Therapeutic interventions have also facilitated translational understanding in a reverse way. However, with improved technology, access to patient samples remains a rate-limiting step in translational research. We anticipate that next-generation neuroimmunology is likely to integrate, in the immediate future, diverse technical tools for optimal diagnosis, prognosis, and treatment of neuroimmunological disorders.
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