期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 31, 期 11, 页码 818-834出版社
CELL PRESS
DOI: 10.1016/j.tem.2020.02.012
关键词
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资金
- National Natural Science Foundation of China [81720108032, 81930109, 81973556]
- Fundamental Research Funds for the Central Universities, China [2632019ZD07, 2242019K3DZ07]
- Project for Major New Drug Innovation and Development [2018ZX09711001-002-003]
Gut microbial metabolism is intimately coupled with host health and disease. Aromatic amino acid (AAA) catabolism by the gut microbiome yields numerous metabolites that may regulate immune, metabolic, and neuronal responses at local and distant sites. Such a chemical dialog between host cells and the gut microbiome is shaped by environmental cues, and may become dysregulated in gastrointestinal and systems diseases. Increasing knowledge of the bacterial pathway and signaling basis may shed additional light on metabolic host-microbiome crosstalk that remains untapped for drug discovery. Here, we update our understanding of microbial AAA metabolism and its impacts on host physiology and disease. We also consider open questions related to therapeutically mining these signaling metabolites and how recent concepts and tools may drive this area forward.
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