期刊
TRENDS IN CELL BIOLOGY
卷 30, 期 7, 页码 566-576出版社
CELL PRESS
DOI: 10.1016/j.tcb.2020.04.004
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资金
- Eli and Edythe Broad Stem Cell Research Center at UCLA
- American Cancer Society [RSG-16-111-01-MPC]
- NIH/NIAMS [R01 AR070245]
- UCLA Jonsson Comprehensive Cancer Center
- Eli and Edythe Broad Center for Regenerative Medicine Ablon Scholars Program
- NIH/NCI [R01 CA215185]
Adult tissue stem cells mediate organ homeostasis and regeneration and thus are continually making decisions about whether to remain quiescent, proliferate, or differentiate into mature cell types. These decisions often integrate external cues, such as energy balance and the nutritional status of the organism. Metabolic substrates and byproducts that regulate epigenetic and signaling pathways are now appreciated to have instructive rather than bystander roles in regulating cell fate decisions. In this review, we highlight recent literature focused on how metabolites and dietary manipulations can impact cell fate decisions, with a focus on the regulation of adult tissue stem cells.
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