期刊
TRENDS IN CELL BIOLOGY
卷 30, 期 5, 页码 354-369出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2020.02.006
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类别
资金
- Volkswagen Foundation [VW 90315]
- Wilhelm Sander-Stiftung [2017.008.01]
- Center of dynamic systems (CDS) - EU-programme ERDF (European Regional Development Fund)
- DFG [LA 2386]
- Russian Foundation for Basic Research [19-54-45015]
- Russian State Budget Project [AAAA-A17-117092070032-4]
Apoptosis is a form of programmed cell death, deregulation of which occurs in multiple disorders, including neurodegenerative and autoimmune diseases as well as cancer. The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. Post-translational modifications (PTMs) of DED-containing DISC components such as FADD, procaspase-8, and c-FLIP comprise an additional level of apoptosis regulation, which is necessary to overcome the threshold for apoptosis induction. In this review we discuss the influence of PTMs of FADD, procaspase-8, and c-FLIP on DED filament assembly and cell death induction, with a focus on the 3D organization of the DED filament.
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