期刊
TRENDS IN BIOTECHNOLOGY
卷 38, 期 12, 页码 1397-1414出版社
CELL PRESS
DOI: 10.1016/j.tibtech.2020.04.006
关键词
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资金
- Programa Operacional Competitividade e Internacionalizacao (POCI), in the component FEDER
- national funds (OE) through FCT/MCTES [PTDC/BTM-SAL/30503/2017]
- project PANGEIA [PTDC/BTM-SAL/30503/2017]
- Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/141718/2018]
- national funds through the Portuguese Foundation for Science and Technology/MCTES [UIDB/50011/2020, UIDP/50011/2020]
- Fundação para a Ciência e a Tecnologia [PTDC/BTM-SAL/30503/2017, SFRH/BD/141718/2018] Funding Source: FCT
Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the tumor microenvironment. We review current and upcoming methodologies for chemical modification of dECM-based biomaterials and advanced bioprocessing into organotypic 3D solid tumor models. A comprehensive review of disruptive advances and shortcomings of exploring dECM-based biomaterials for recapitulating the native tumor-supporting matrix is also provided. We hope to drive the discussion on how 3D dECM testing platforms can be leveraged for generating microphysiological tumor surrogates that generate more robust and predictive data on therapeutic bioperformance.
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