期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 45, 期 9, 页码 764-778出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2020.05.002
关键词
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资金
- National Institutes of Health (NIH) Signaling and Cellular Regulation training grant [T32GM08759]
- NIH [RO1 GM045443]
- Howard Hughes Medical Institute
Ribonucleoprotein (RNP) granules are RNA-protein assemblies that are involved in multiple aspects of RNA metabolism and are linked to memory, development, and disease. Some RNP granules form, in part, through the formation of intermolecular RNA-RNA interactions. In vitro, such trans RNA condensation occurs readily, suggesting that cells require mechanisms to modulate RNA-based condensation. We assess the mechanisms of RNA condensation and how cells modulate this phenomenon. We propose that cells control RNA condensation through ATP-dependent processes, static RNA buffering, and dynamic post-translational mechanisms. Moreover, perturbations in these mechanisms can be involved in disease. This reveals multiple cellular mechanisms of kinetic and thermodynamic control that maintain the proper distribution of RNA molecules between dispersed and condensed forms.
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