期刊
TRANSLATIONAL RESEARCH
卷 221, 期 -, 页码 23-43出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2020.03.012
关键词
-
资金
- National Institutes of Health [1K23AI125715, R01AG060825]
- Robert Wood Johnson Foundation Harold Amos Award
- Willowcroft Foundation grant
- Johns Hopkins University Center for AIDS Research (JHU-CFAR)
- NIH [P30AI094189]
- (SPARC) program grant for HIV gut microbiome research
The human microbiome is constituted by an extensive network of organisms that lie at the host/environment interface and transduce signals that play vital roles in human health and disease across the lifespan. Frailty is a critical aging-related syndrome marked by diminished physiological reserve and heightened vulnerability to stress, predictive of major adverse clinical outcomes including death. While recent studies suggest the microbiome may impact key pathways critical to frailty pathophysiology, direct evaluation of the microbiome-frailty relationship remains limited. In this article, we review the complex interplay of biological, behavioral, and environmental factors that may influence shifts in gut microbiome composition and function in aging populations and the putative implications of such shifts for progression to frailty. We discuss HIV infection as a key prototype for elucidating the complex pathways via which the microbiome may precipitate frailty. Finally, we review considerations for future research efforts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据