期刊
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
卷 125, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2020.115842
关键词
Lateral flow assay; Early cancer detection; Biomarker; Point-of-care analysis; Sensitivity enhancement
资金
- Iran National Science Foundation (INSF) [97001910]
- Tabriz University of Medical Sciences [60836]
- Immunology Research Center, Tabriz University of Medical Sciences, Tabriz-Iran
Cancer is one of the main causes of mortality and morbidity worldwide. However, its early non-invasive detection via quantification of appropriate biomarkers can significantly reduce mortality, enhance survival, and save treatment costs. Lateral flow test strips (LFTS) are nowadays considered as the most attractive point-of-care devices for healthcare applications. However, the quantification of cancer biomarkers in body fluids suffers from some challenges including i) the necessity for multiplex analysis, ii) the development of sensitive detection systems, iii) to overcome the analysis of complex samples, at the same time, it should keep the quality assurance criteria for an accurate and proper diagnostic. This review provides an overview of recent advances, the current challenges and available solutions in cancer biomarkers detection via LFTS focusing on the sensitivity enhancement by various detection systems. Then, the available LFTS kits in the market are presented and future trends in this area are foreseen. (c) 2020 Elsevier B.V. All rights reserved.
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