期刊
THROMBOSIS AND HAEMOSTASIS
卷 120, 期 4, 页码 538-564出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1708035
关键词
thrombosis; inflammation; coagulation; pulmonary embolism; myocardial infarction; stroke; platelets
资金
- European Union [766118]
- Netherlands Heart Foundation [CVON2014-09]
Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
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