期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 41, 页码 14513-14517出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603057
关键词
ball milling; mechanochemistry; silica; Strecker reaction; tetrahydroisoquinolines
资金
- Distinguished Professorship Program - Excellence Initiative of the German Federal and State Governments
A mechanochemical version of the Strecker reaction for the synthesis of -aminonitriles was developed. The milling of aldehydes, amines, and potassium cyanide in the presence of SiO2 gave the corresponding -aminonitriles in good to high yields. The high efficiency of the mechanochemical Strecker-type multicomponent reaction allowed the one-pot synthesis of tetrahydroisoquinolines after a subsequent internal N-alkylation reaction.
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