期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 36, 页码 12651-12654出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201603021
关键词
bipyridine; G4 ligand; G-quadruplex; helicase; terpyridine
资金
- Agence Nationale de la Recherche [ANR-12-BSV8-0008-01, ANR-10-NANO-04-03]
- Conseil Regional d'Aquitaine
- ANRS
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche (ANR) [ANR-12-BSV8-0008] Funding Source: Agence Nationale de la Recherche (ANR)
G-quadruplexes formed by nucleic acids are implicated in pathologies ranging from cancers to neurodegenerative diseases. We evaluated interactions of 29 bi- and terpyridine derivatives with G-quadruplexes and duplexes. FRET-melting, circular dichroism, and H-1 NMR spectroscopy showed that one terpyridine derivative interacted very selectively with G-quadruplexes. This G-quadruplex ligand inhibited helicase activity and should influence G-quadruplex-related biological processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据