期刊
TETRAHEDRON LETTERS
卷 61, 期 20, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.151852
关键词
Marine sponge; Triterpene galactoside; Melophlus sarasinorum; Structure elucidation
资金
- JSPS KAKENHI [26305005, 17H03994, 18K14933]
- Grants-in-Aid for Scientific Research [18K14933, 17H03994] Funding Source: KAKEN
Two new triterpene galactosides, melophluosides A and B, were isolated from a marine sponge Melophlus sarasinorum collected in Indonesia. Their structures were determined by the analysis of spectroscopic data and chemical reactions. The absolute configuration of cyclohexenone moiety was determined by the calculated ECD spectrum of a simplified model. Melophluosides A and B exhibited moderate cytotoxicity against HeLa cells (IC50, 11.6 and 9.7 mu M, respectively). (C) 2020 Elsevier Ltd. All rights reserved.
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